Automated free energy calculations for the prediction of binding free energies of congeneric series of ligands to a protein target are growing in popularity, but building reliable initial binding poses for the ligands is challenging. Here, we
Covid-19 disease, as a common infectious disease, has caused infection and death. Preventive behaviors are among the most important essential strategies of the Covid-19 disease prevention and control program. The health belief model (HBM) is one of
The prone position is a crucial position used in the operating rooms and the intensive care units, with its importance highly recognized during the COVID-19 pandemic in patients with acute respiratory distress syndrome (ARDS). Cardiopulmonary
An essential target for COVID-19 is the main protease of SARS-CoV-2 (M^(pro)). With the objective of targeting this receptor, a novel set of pyrido[1,2-a]pyrrolo[2,3-d]pyrimidines with terminal carboxamide fragments was designed, synthesized, and
Antiviral and inflammatory responses following the detection of the virus genome by nucleic acid sensors play a vital role in the pathogenesis and outcome of diseases. In this study, we investigated the ZBP1, AIM2, and MDA5 expression levels in COVID
An innovative ADE-TFT interpretable tourism demand forecasting model was proposed to address the issue of the insufficient interpretability of existing tourism demand forecasting. This model effectively optimizes the parameters of the Temporal Fusion
CONCLUSIONS: A dental curriculum emphasizing Evidence-based practice (EBD) resulted in increased knowledge acquisition, improved attitude, and confidence toward EBD of dental students.
CONCLUSION: The participants exhibited acceptable knowledge and attitude, with respondents from private universities and dental assistance attaining better knowledge scores. More infection control programs and training courses should be implemented
CONCLUSIONS: No significant intensification of anxiety and depression symptoms was observed among medical personnel during the first wave of the pandemic. Health-promoting behaviors, and especially positive mental attitudes, may play a protective